Ammonium → 6-(1H-pyrazol-1-yl)pyrimidin-4-amine

Reaction equation

[CH2:15]([Cl:16])[Cl:17].[Cl:1][c:2]1[cH:3][c:4](-[n:8]2[n:9][cH:10][cH:11][cH:12]2)[n:5][cH:6][n:7]1.[NH4+:13].[OH-:14]>>[c:2]1([NH2:13])[cH:3][c:4](-[n:8]2[n:9][cH:10][cH:11][cH:12]2)[n:5][cH:6][n:7]1

Participants

Reactant 4

HCID 223Ammonium

HCID 961Hydroxide

HCID 6344Dichloromethane

HCID 106312394-Chloro-6-(1H-pyrazol-1-yl)pyrimidine

Product 1

HCID 107494946-(1H-pyrazol-1-yl)pyrimidin-4-amine

Sources & evidence

ORD record: ord-65140d1770394616938292d8c7831da6
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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