4-Aminomethyltetrahydropyran → (7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine

Participants

Role	Name	HCID	Charge
Reactant	4-Aminomethyltetrahydropyran	HCID 2773210	—
Reactant	7-Bromo-4-chloro-3-nitroquinoline	HCID 21984361	—
Product	(7-Bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine	HCID 21984259	94.3%

Reaction Steps

The method described in Part E of Examples 431–436 was used to treat 7-bromo-4-chloro-3-nitroquinoline (12.43 g, 43.45 mmol) with C-(tetrahydropyran-4-yl)methylamine (10 g, 87 mmol) to provide 15.0 g of (7-bromo-3-nitroquinolin-4-yl)(tetrahydropyran-4-ylmethyl)amine as a bright yellow solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07091214B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-f146f725e49749349a288d4b0e2fcd92
Source note	uspto-grants-2006_08