Diethyl Ether → Methyl {[5'-acetyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}[3,5-bis(trifluoromethyl)benzyl]carbamate

HRID 947346

Reaction equation

HRID 947346 reaction equation
[CH2:43]([Cl:44])[Cl:45].[CH3:46][CH2:47][O:48][CH2:49][CH3:50].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([C:8]([O:9][CH3:10])=[O:11])[CH2:12][c:13]2[c:14](-[c:23]3[c:24]([O:32][CH3:33])[cH:25][cH:26][c:27]([CH:29]([CH3:30])[OH:31])[cH:28]3)[cH:15][cH:16][c:17]([C:19]([F:20])([F:21])[F:22])[cH:18]2)[cH:34][c:35]([C:37]([F:38])([F:39])[F:40])[cH:36]1)([F:41])[F:42]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([C:8]([O:9][CH3:10])=[O:11])[CH2:12][c:13]2[c:14](-[c:23]3[c:24]([O:32][CH3:33])[cH:25][cH:26][c:27]([C:29]([CH3:30])=[O:31])[cH:28]3)[cH:15][cH:16][c:17]([C:19]([F:20])([F:21])[F:22])[cH:18]2)[cH:34][c:35]([C:37]([F:38])([F:39])[F:40])[cH:36]1)([F:41])[F:42]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 11599738Methyl [3,5-bis(trifluoromethyl)benzyl]{[5'-(1-hydroxyethyl)-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}carbamate

Product 1

HCID 11563435Methyl {[5'-acetyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]methyl}[3,5-bis(trifluoromethyl)benzyl]carbamate

Sources & evidence

ORD record
ord-08470dbdf7c74b22afdc61d3d906c17e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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