1,2-Dimethoxyethane → [3-(2-Bromomethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Reaction equation

[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][c:6]1[cH:7][c:8]([O:14][c:15]2[c:16]([CH2:22][OH:23])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[c:9]([O:12][CH3:13])[cH:10][cH:11]1)=[O:24].[CH3:29][O:30][CH2:31][CH2:32][O:33][CH3:34].[P:25]([Br:26])([Br:27])[Br:28]>>[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][c:6]1[cH:7][c:8]([O:14][c:15]2[c:16]([CH2:22][Br:26])[cH:17][c:18]([Cl:21])[cH:19][cH:20]2)[c:9]([O:12][CH3:13])[cH:10][cH:11]1)=[O:24]

Participants

Reactant 3

HCID 80711,2-Dimethoxyethane

HCID 24614Phosphorus tribromide

HCID 58237450[3-(4-Chloro-2-hydroxymethyl-phenoxy)-4-methoxy-phenyl]acetic acid ethyl ester

Product 1

HCID 58237456[3-(2-Bromomethyl-4-chloro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Sources & evidence

ORD record: ord-c5fa4e6487914e38b61511b5db58e429
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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