Synephrine → 5-[[1-[[4-Chloro-2-(trifluoromethyl)phenyl]methyl]indazol-5-yl]methylidene]-2-[[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylamino]-1,3-thiazol-4-one

HRID 951815

Reaction equation

HRID 951815 reaction equation
[Cl:1][c:2]1[cH:3][c:4]([C:27]([F:28])([F:29])[F:30])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:24])[NH:19][CH:20]([S:22][CH3:23])[S:21]4)[cH:13][cH:14][c:15]23)[cH:25][cH:26]1.[OH:31][CH:32]([CH2:33][NH:34][CH3:35])[c:36]1[cH:37][cH:38][c:39]([OH:42])[cH:40][cH:41]1>>[Cl:1][c:2]1[cH:3][c:4]([C:27]([F:28])([F:29])[F:30])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:24])[N:19]=[C:20]([N:34]([CH2:33][CH:32]([OH:31])[c:36]5[cH:37][cH:38][c:39]([OH:42])[cH:40][cH:41]5)[CH3:35])[S:21]4)[cH:13][cH:14][c:15]23)[cH:25][cH:26]1

Participants

3

Reactant 2

HCID 7172SynephrineHCID 866565225-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-methylsulfanyl-thiazolidin-4-one

Product 1

HCID 673489945-[[1-[[4-Chloro-2-(trifluoromethyl)phenyl]methyl]indazol-5-yl]methylidene]-2-[[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-methylamino]-1,3-thiazol-4-one

Sources & evidence

ORD record
ord-556364b9cefa4bcda52dd4c78c55f1a9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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