methyl 4-(bromomethyl)-2-fluorobenzoate → 3-tert-butoxycarbonyl-7-chloro-6-(3-fluoro-4-methoxycarbonylbenzylthio)-2,3,4,5-tetrahydro-1H-benzo[d]azepine
Reaction equation
[Br:26][CH2:27][c:28]1[cH:29][c:30]([F:38])[c:31]([C:32](=[O:33])[O:34][CH3:35])[cH:36][cH:37]1.[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[c:12]([c:15]([S:20][C:21](=[O:22])[N:23]([CH3:24])[CH3:25])[c:16]([Cl:19])[cH:17][cH:18]2)[CH2:13][CH2:14]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][c:11]2[c:12]([c:15]([S:20][CH2:27][c:28]3[cH:29][c:30]([F:38])[c:31]([C:32](=[O:33])[O:34][CH3:35])[cH:36][cH:37]3)[c:16]([Cl:19])[cH:17][cH:18]2)[CH2:13][CH2:14]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-9a87ee079dc54584a8d6f9e6a4f171e9
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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