tert-Butyl 2-(2-methylpropyl)piperazine-1-carboxylate → tert-butyl 4-[6-[(3-amino-2-oxo-1H-quinoxalin-5-yl)oxy]-2-(1-methoxypropan-2-ylamino)pyrimidin-4-yl]-2-(2-methylpropyl)piperazine-1-carboxylate

HRID 956715

Reaction equation

HRID 956715 reaction equation
[CH2:27]([CH:28]([CH3:29])[CH3:30])[CH:31]1[N:32]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:33][CH2:34][NH:35][CH2:36]1.[NH2:1][c:2]1[c:3](=[O:26])[nH:4][c:5]2[cH:6][cH:7][cH:8][c:9]([O:12][c:13]3[n:14][c:15]([NH:20][CH:21]([CH2:22][O:23][CH3:24])[CH3:25])[n:16][c:17]([Cl:19])[cH:18]3)[c:10]2[n:11]1>>[NH2:1][c:2]1[c:3](=[O:26])[nH:4][c:5]2[cH:6][cH:7][cH:8][c:9]([O:12][c:13]3[n:14][c:15]([NH:20][CH:21]([CH2:22][O:23][CH3:24])[CH3:25])[n:16][c:17]([N:35]4[CH2:34][CH2:33][N:32]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH:31]([CH2:27][CH:28]([CH3:29])[CH3:30])[CH2:36]4)[cH:18]3)[c:10]2[n:11]1

Participants

3

Reactant 2

HCID 45073240tert-Butyl 2-(2-methylpropyl)piperazine-1-carboxylateHCID 877322543-amino-5-[6-chloro-2-(1-methoxypropan-2-ylamino)pyrimidin-4-yl]oxy-1H-quinoxalin-2-one

Product 1

HCID 90993736tert-butyl 4-[6-[(3-amino-2-oxo-1H-quinoxalin-5-yl)oxy]-2-(1-methoxypropan-2-ylamino)pyrimidin-4-yl]-2-(2-methylpropyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-c8812bfbae1f4315a441bca7fb6111a4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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