Acetonitrile → N-(4,4-Dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)-4-oxo-1H-quinoline-3-carboxamide

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][C:11]([CH3:32])([CH3:33])[c:12]2[cH:13][cH:14][c:15]([NH:18][C:19](=[O:20])[c:21]3[cH:22][nH:23][c:24]4[cH:25][cH:26][cH:27][cH:28][c:29]4[c:30]3=[O:31])[cH:16][c:17]21)([CH3:5])([CH3:6])[CH3:7].[CH3:34][C:35]#[N:36]>>[NH:8]1[CH2:9][CH2:10][C:11]([CH3:32])([CH3:33])[c:12]2[cH:13][cH:14][c:15]([NH:18][C:19](=[O:20])[c:21]3[cH:22][nH:23][c:24]4[cH:25][cH:26][cH:27][cH:28][c:29]4[c:30]3=[O:31])[cH:16][c:17]21

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 666756994,4-dimethyl-7-[(4-oxo-1H-quinolin-3-yl)carbonylamino]-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester

Product 1

HCID 57470277N-(4,4-Dimethyl-1,2,3,4-tetrahydroquinolin-7-yl)-4-oxo-1H-quinoline-3-carboxamide

Sources & evidence

ORD record: ord-2a4ab23cfee5451aa9dd64dc0be36199
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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