Methanol → 6-(4-chloro-1H-imidazol-1-yl)pyridin-3-amine

Reaction equation

[CH3:21][OH:22].[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][cH:9][c:10]([N+:13]([O-:14])=[O:15])[cH:11][cH:12]2)[cH:6]1.[OH2:16].[OH2:17].[Sn:18]([Cl:19])[Cl:20]>>[Cl:1][c:2]1[n:3][cH:4][n:5](-[c:7]2[n:8][cH:9][c:10]([NH2:13])[cH:11][cH:12]2)[cH:6]1

Participants

Reactant 4

HCID 887Methanol

HCID 962Water2×

HCID 24479Stannous Chloride

HCID 681568572-(4-chloro-1H-imidazol-1-yl)-5-nitropyridine

Product 1

HCID 681575046-(4-chloro-1H-imidazol-1-yl)pyridin-3-amine

Sources & evidence

ORD record: ord-8aca289d98134f12ab9e17ae53dadf8a
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…