Toluene → 2-Methyl-6-(trifluoromethyl)nicotinoyl chloride

HRID 960232

Reaction equation

HRID 960232 reaction equation
[CH3:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1.[CH3:5][c:6]1[c:7]([C:8](=[O:9])[OH:10])[cH:11][cH:12][c:13]([C:15]([F:16])([F:17])[F:18])[n:14]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:3][C:8]([c:7]1[c:6]([CH3:5])[n:14][c:13]([C:15]([F:16])([F:17])[F:18])[cH:12][cH:11]1)=[O:9]

Participants

4

Reactant 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 27756832-Methyl-6-(trifluoromethyl)nicotinic acid

Product 1

HCID 27756752-Methyl-6-(trifluoromethyl)nicotinoyl chloride

Sources & evidence

ORD record
ord-1a2ad5e92a8343cdaf10ae9a5d528ef5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Linked notes

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