Aluminium lithium hydride → 1-(2-Fluoro-3-hydroxyprop-1-enyl)-1-(4-trifluoromethoxyphenyl)cyclopropane
Reaction equation
[F:1][C:2]([C:18](OC)=[O:19])=[CH:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=2)[CH2:6][CH2:5]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[F:1][C:2]([CH2:18][OH:19])=[CH:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([O:13][C:14]([F:16])([F:15])[F:17])=[CH:9][CH:8]=2)[CH2:5][CH2:6]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The method of Example 9 was repeated using 1-(2-fluoro-2-(methoxycarbonyl)ethenyl)1-(4-trifluoromethoxyphenyl)cyclopropane (Example 3) (0.39 g), diethyl ether (10 ml) and lithium aluminium hydride (0.11 g) to yield the title compound (0.28 g, 80%).