Oxalic Acid → HCID 87238501, compound
Reaction equation
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]>C(O)C.O>[OH2:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Analogously to Example 7 a solution of 2.3 g sodium phenolate and 2.5 g N-3-chloropropyl-N-[5-(4-fluorophenyl)-3-pyridylmethyl]-amine [obtainable by reaction of 3-hydroxypropylamine with 3-chloromethyl-5-(4-fluorophenyl)-pyridine and subsequent transformation of the product to the 3-chloropropyl-compound by reaction with PCl3 ] in 200 ml of acetonitrile is stirred for 5 hours at room temperature and worked up in a conventional manner to give N-(3-phenoxy-propyl)-N-[5-(4-fluorophenyl)-3-pyridyl-methyl]-amine. Stirring with Q5 equivalents of oxalic acid in 100 ml ethanol/water mixture gives the oxalate-hemihydrate, m.p. 217°.
Sources & evidence
- ORD record
- ord-8d963b9d660c4eba8c897e732f901d24
- Source dataset
- uspto-grants-1998_06
- Patent number
- US05767132
Reaction notes
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