Methyl iodide → 3-(4-Butoxy-1,2,5-thiadiazol-3-yl)-1-methylpyridinium iodide
Reaction equation
[CH3:1][I:2].[CH2:3]([O:7][C:8]1[C:12]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[N:11][S:10][N:9]=1)[CH2:4][CH2:5][CH3:6]>CC(C)=O>[I-:2].[CH2:3]([O:7][C:8]1[C:12]([C:13]2[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=2)=[N:11][S:10][N:9]=1)[CH2:4][CH2:5][CH3:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of methyl iodide (0.3 ml, 5 mmol) and 3-(3-butoxy-1,2,5-thiadiazol-4-yl)pyridine (580 mg, 2.5 mmol) in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration to yield 0.60 g (64%).
Workup
- customThe title compound precipitated from the solution
- filtrationwas collected by filtration
- customto yield 0.60 g (64%)
Sources & evidence
- ORD record
- ord-63270f4e2525471e82096895ee8467fc
- Source dataset
- uspto-grants-1998_06
- Patent number
- US05773452
Reaction notes
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