Water → HCID 21986453, compound

HRID 9654

Reaction equation

HRID 9654 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[S:17][CH:18]=[CH:19][CH:20]=2)=[CH:9][C:8]=1[CH3:21])[CH3:2].[Br:23]Br.O>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][C:16]2[S:17][C:18]([Br:23])=[CH:19][CH:20]=2)=[CH:9][C:8]=1[CH3:21])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 21986308Ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate2×

Product 1

HCID 21986453HCID 21986453, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate (intermediate 69, 0.306 g) in acetic acid (5 ml) was treated with bromine (0.180 g) at ambient temperature and the mixture stirred for 15 minutes. The mixture was poured into water and the resulting suspension extracted with diethyl ether. The organic layer was separated, dried over sodium sulfate and concentrated to give the title compound as a colourless oil.

Workup

  1. extractionthe resulting suspension extracted with diethyl ether
  2. customThe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-7637624903df403d86dd6f4ca5b896ea
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

Loading…