HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 965490Generated: October 23, 2026
Tri-o-tolylphosphine → Ethyl (E)-4-[2-(5,6-dihydro-5,5-dimethyl-8-(phenylthio)naphthalenyl)ethenyl]benzoate
https://huagongshe.com/en/reaction/965490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tri-o-tolylphosphine | HCID 80271 | — |
| Reactant | Ethyl 4-vinylbenzoate | HCID 10866858 | — |
| Reactant | 4,4-Dimethyl-7-bromo-1-phenylthio-3,4-dihydronaphthalene | HCID 15896018 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Ethyl (E)-4-[2-(5,6-dihydro-5,5-dimethyl-8-(phenylthio)naphthalenyl)ethenyl]benzoate | HCID 19695074 | — |
Reaction Steps
To a degassed solution of 0.35 g (1.0 mmol) of 2-bromo-5,6-dihydro-5,5-dimethyl-8-(phenylthio)-naphthalene (Compound A35) and 0.34 g (1.9 mmol) of ethyl 4-vinylbenzoate in 4.0 mL of triethylamine, was added 0.066 g (0.2 mmol) of tri-o-tolylphosphine and then 0.025 g (0.1 mmol) of palladium(II) acetate. The reaction was heated at 90° C. for 2.25 h. The reaction was concentrated in vacuo. The residue was purified by flash chromatography (silica, 5% ethyl acetate in hexane), followed by recrystallization using EtOH to afford the title compound as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05773594 |
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| Source dataset | uspto-grants-1998_06 |
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| ORD ID | ord-b8ee9d94292e43ad9d037d4aaa1e830e |
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| Source note | uspto-grants-1998_06 |
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