4-(2,3-Difluoro-phenyl)-1,3-dihydro-indol-2-one → 2-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

HRID 96581

Reaction equation

HRID 96581 reaction equation
[CH3:1][c:2]1[c:3]([CH:19]=[O:20])[nH:4][c:5]2[c:6]1[C:7](=[O:18])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17]1)[CH2:9][CH2:10]2.[F:21][c:22]1[c:23](-[c:29]2[c:30]3[c:34]([cH:35][cH:36][cH:37]2)[NH:33][C:32](=[O:38])[CH2:31]3)[cH:24][cH:25][cH:26][c:27]1[F:28]>>[CH3:1][c:2]1[c:3]([CH:19]=[C:31]2[c:30]3[c:29](-[c:23]4[c:22]([F:21])[c:27]([F:28])[cH:26][cH:25][cH:24]4)[cH:37][cH:36][cH:35][c:34]3[NH:33][C:32]2=[O:38])[nH:4][c:5]2[c:6]1[C:7](=[O:18])[N:8]([CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH2:16][CH2:17]1)[CH2:9][CH2:10]2

Participants

3

Reactant 2

HCID 225619714-(2,3-Difluoro-phenyl)-1,3-dihydro-indol-2-oneHCID 866376753-methyl-4-oxo-5-(2-pyrrolidin-1-yl-ethyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 666084502-[4-(2,3-Difluoro-phenyl)-2-oxo-1,2-dihydro-indol-3-ylidenemethyl]-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-80afb932651a42e1884155d5fd88b66d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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