2-Mesityl-3-nitropyridine → 2-Mesityl-3-pyridinamine

HRID 966014

Reaction equation

HRID 966014 reaction equation
[C:1]1([CH3:18])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:14]([N+:15]([O-])=O)=[CH:13][CH:12]=[CH:11][N:10]=1>C(O)C.[H][H].[C].[Pd]>[C:1]1([CH3:18])[CH:6]=[C:5]([CH3:7])[CH:4]=[C:3]([CH3:8])[C:2]=1[C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

5

Reactant 1

HCID 222494912-Mesityl-3-nitropyridine

Product 1

HCID 167414262-Mesityl-3-pyridinamineYield 106.5%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

Palladium-carbon (10%, 0.6 g) was added to a solution of 2-mesityl-3-nitropyridine (5.99 g, 23 mmol) in ethanol (120 mL), followed by stirring for one day in hydrogen atmospher. The mixture was filtered through Celite and evaporated, to give the title compound (5.2 g) as white crystals.

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customevaporated

Sources & evidence

ORD record
ord-c73ee1167547434ca4212285a5e42e77
Source dataset
uspto-grants-2005_10
Patent number
US06951865B2

Linked notes

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