N-Methylisopropylamine → {2-{[Isopropyl(methyl)amino]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

HRID 9662

Reaction equation

Br[CH2:2][C:3]1[O:4][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:6][C:7]=1[C:8]([O:10]C)=O.[CH3:22][NH:23][CH:24]([CH3:26])[CH3:25]>>[CH:24]([N:23]([CH2:2][C:3]1[O:4][C:5]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[CH:6][C:7]=1[CH2:8][OH:10])[CH3:22])([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 78485N-Methylisopropylamine

HCID 21986318Methyl 2-bromomethyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

Product 1

HCID 21986358{2-{[Isopropyl(methyl)amino]methyl}-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol

Procedure

Prepared using intermediate 44 and N-methylisopropylamine. This compound was used directly without collection of analytical data for the preparation of Example 75.

Workup

customPrepared
customThis compound was used directly without collection of analytical data for the preparation of Example 75

Sources & evidence

ORD record: ord-0859d51250d044c38378d9f0c267c973
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091237B2

Linked notes

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