Hydrazine → 2-Pyrazinepropanamine
Reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[CH2:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.NN>C(Cl)(Cl)Cl>[NH2:10][CH2:9][CH2:8][CH2:7][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
N-[3-(2-Pyrazinyl)propyl]phthalimide (521 mg, 1.95 mmol) was dissolved in chloroform (15 mL) followed by addition of anhydrous hydrazine (1.5 mL), and then the mixture was stirred at room temperature for 20 hours. The resulting precipitate was removed by filtration, and the filtrate was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and 2-(3-aminopropyl)pyrazine (240 mg; yield 90%) was thus obtained.
Workup
- customThe resulting precipitate was removed by filtration
- washthe filtrate was washed with water
- dry with materialdried over anhydrous sodium sulfate
Sources & evidence
- ORD record
- ord-9ce6b49e5a90408284179b193747c0f3
- Source dataset
- uspto-grants-2005_10
- Patent number
- US06953785B2
Reaction notes
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