{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

HRID 9677

Reaction equation

HRID 9677 reaction equation
CC1C=C(C2C=CC(OC(F)(F)[F:15])=CC=2)SC=1CO.F[C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[C:24]([F:31])=[CH:23][C:22]=1[C:32]1[S:36][C:35]([CH2:37][O:38][Si](C(C)C)(C(C)C)C(C)C)=[C:34]([CH3:49])[CH:33]=1>>[F:15][C:23]1[C:24]([F:31])=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=[CH:21][C:22]=1[C:32]1[S:36][C:35]([CH2:37][OH:38])=[C:34]([CH3:49])[CH:33]=1

Participants

3

Reactant 2

HCID 21986356{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol2×HCID 69591148({5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane2×

Product 1

HCID 21986476{5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

Procedure

The title compound was prepared using a method analogous to that used for the preparation of {3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 121).

Sources & evidence

ORD record
ord-2e228b351c7c43fba1014b597e7acab5
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

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