{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

HRID 9678

Reaction equation

HRID 9678 reaction equation
CC1C=C(C2C=CC(OC(F)(F)F)=CC=2)SC=1CO.[F:20][C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=1[C:31]1[S:35][C:34]([CH2:36][O:37][Si](C(C)C)(C(C)C)C(C)C)=[C:33]([CH3:48])[CH:32]=1>>[F:20][C:21]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=1[C:31]1[S:35][C:34]([CH2:36][OH:37])=[C:33]([CH3:48])[CH:32]=1

Participants

3

Reactant 2

HCID 21986356{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol2×HCID 69591680({5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane2×

Product 1

HCID 21986424{5-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol

Procedure

The title compound was prepared using a method analogous to that used for the preparation of {{3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2-fluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 123).

Sources & evidence

ORD record
ord-ab42de0f5742458eae6065e2d141c665
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

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