4-Methoxybenzenesulfonamide → 4-methoxy-N-[({2-[4-(2-ethyl-4-phenyl-1H-imidazol-1-yl)phenyl]ethyl}amino)carbonyl]benzenesulfonamide

HRID 967828

Reaction equation

HRID 967828 reaction equation
[CH2:1]([C:3]1[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O-:24])=[CH:16][CH:15]=2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1)[CH3:2].[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([S:34]([NH2:37])(=[O:36])=[O:35])=[CH:30][CH:29]=1>>[CH3:26][O:27][C:28]1[CH:29]=[CH:30][C:31]([S:34]([NH:37][C:23]([NH:22][CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:14]([N:4]3[CH:5]=[C:6]([C:8]4[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=4)[N:7]=[C:3]3[CH2:1][CH3:2])=[CH:19][CH:18]=2)=[O:24])(=[O:36])=[O:35])=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 707894-MethoxybenzenesulfonamideHCID 222913502-[4-(2-ethyl-4-phenyl-1H-imidazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 222913534-methoxy-N-[({2-[4-(2-ethyl-4-phenyl-1H-imidazol-1-yl)phenyl]ethyl}amino)carbonyl]benzenesulfonamide

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from 2-[4-(2-ethyl-4-phenyl-1H-imidazol-1-yl)phenyl]ethylcarbamate and 4-methoxybenzenesulfonamide. MS (ESI) m/z 505 [M+H]+, 503 [M−H]−, 1H-NMR (CDCl3) δ 1.25 (3H, t, J=7.5 Hz), 2.72 (2H, q, J=7.5 Hz), 2.91 (2H, t, J=6.8 Hz), 3.40-3.55 (2H, m), 6.64 (1H, br), 6.96 (2H, d, J=9.0 Hz), 7.20-7.30 (5H, m), 7.38 (2H, t, J=7.3 Hz), 7.74 (2H, d, J=9.0 Hz), 7.79 (2H, d, J=8.4 Hz).

Sources & evidence

ORD record
ord-8469e0c746d140fd96f5c4308af0aef9
Source dataset
uspto-grants-2005_10
Patent number
US06956050B2

Linked notes

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