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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9681Generated: October 26, 2026

4-[4-(Trifluoromethyl)phenyl]thiophene-2-carboxylic acid → 3-Methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylic acid

https://huagongshe.com/reaction/9681

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[4-(Trifluoromethyl)phenyl]thiophene-2-carboxylic acidHCID 21986512—
Reactant3-Methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehydeHCID 21986550—
Product3-Methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylic acidHCID 21986349—

Reaction Steps

The title compound was prepared using 3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene-2-carbaldehyde (intermediate 74) by a method analogous to the preparation of 4-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylic acid (intermediate 38).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-b32d3278f4144988a796a1120977547e
Source noteuspto-grants-2006_08