HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10910823, compound → Spermine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10910823 | HCID 10910823 | — |
| Reactant | TriBoc-Spermine | HCID 22610912 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | Spermine | HCID 1103 | — |
Reaction Steps
Monoquaternary spermine containing hydrophilic head-group was prepared in a similar way to compound 3. Briefly, TriBoc-Spermine was reacted with excess of 1-azido-3-iodo-propane in the presence of excess TBA. The resulting quaternarized derivative was hydrogenised under (Pd—C) and Boc protecting group were removed using gaseous HCl in dry methanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06958325B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-7efc57ded6f7404794f1c0a62996d328 |
| Source note | uspto-grants-2005_10 |