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(R)-(-)-2-Amino-1-propanol → (2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

HRID 968204
Notes
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Reaction equation

HRID 968204 reaction equation
Cl[C:2]1[C:3]2[S:18][C:17]([NH2:19])=[N:16][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:7]=1.[NH2:20][C@H:21]([CH3:24])[CH2:22][OH:23]>>[NH2:19][C:17]1[S:18][C:3]2[C:2]([NH:20][C@H:21]([CH3:24])[CH2:22][OH:23])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:5][C:4]=2[N:16]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

3

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 112782745-(Benzylthio)-7-chloro[1,3]thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 11857680(2R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol

Procedure

Prepared by the method of example 1, step (d), using the product of example 1, step (c) and (R)-(−)-2-amino-1-propanol.

Workup

  1. customPrepared by the method of example 1, step (d)

Sources & evidence

ORD record
ord-0aa7270e48ba406d8759b4fae98ad19b
Source dataset
uspto-grants-2005_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06958343B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes