2-Propanethiol → {3-[(Isopropylthio)methyl]-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

HRID 9683

Reaction equation

Br[CH2:2][C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[S:5][C:4]=1[C:18](OC)=[O:19].[CH3:22][CH:23]([SH:25])[CH3:24]>>[F:16][C:14]([F:15])([F:17])[C:11]1[CH:12]=[CH:13][C:8]([C:6]2[S:5][C:4]([CH2:18][OH:19])=[C:3]([CH2:2][S:25][CH:23]([CH3:24])[CH3:22])[CH:7]=2)=[CH:9][CH:10]=1

Participants

Reactant 2

HCID 63642-Propanethiol

HCID 21986302Methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate2×

Product 1

HCID 21986403{3-[(Isopropylthio)methyl]-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

Procedure

The title compound was prepared using methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate (intermediate 132) and isopropylthiol.

Sources & evidence

ORD record: ord-6955e06f343f4d48a5b3006d7249844a
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07091237B2

Linked notes

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