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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 9685Generated: October 26, 2026

Methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate → {3-{[(2-Isopropyl-6-methylpyrimidin-4-yl)oxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanol

https://huagongshe.com/reaction/9685

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylateHCID 21986302—
ReactantHCID 178419104HCID 178419104—
Product{3-{[(2-Isopropyl-6-methylpyrimidin-4-yl)oxy]methyl}-5-[4-(trifluoromethyl)phenyl]thien-2-yl}methanolHCID 21986496—

Reaction Steps

The title compound was prepared using methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate (intermediate 132) and 2-isopropyl-6-methyl-4-pyrimidinol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07091237B2
Source datasetuspto-grants-2006_08
ORD IDord-af55f1b94a2548bbb8c81307374898be
Source noteuspto-grants-2006_08