Sodium Methoxide → [2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea

HRID 968537Notes

Reaction equation

HRID 968537 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[C:17]([CH:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:16]=[CH:15][C:14]=1[O:25][CH3:26])=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:26][O:25][C:14]1[CH:15]=[CH:16][C:17]([CH:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)=[CH:18][C:13]=1[NH:12][C:10]([NH2:9])=[S:11]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 227195711-Benzoyl-3-[2-methoxy-5-(tetrahydropyran-4-yl)-phenyl]-thiourea

Product 1

HCID 22015747[2-Methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 1-benzoyl-3-[2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea (X) in methanol is added sodium methylate solution and stirring continued for about 1 h at room temperature. The product (XI) [2-methoxy-5-(tetrahydro-pyran-4-yl)-phenyl]-thiourea is isolated by conventional means.

Sources & evidence

ORD record
ord-a782e1606e434c12b23ef122ad852623
Source dataset
uspto-grants-2007_12
Patent number
US07304058B2

Reaction notes

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