4-(1,1-Dimethoxyethyl)pyrimidin-2-amine → 1-(2-Aminopyrimidin-4-yl)ethan-1-one
Reaction equation
C[O:2][C:3]([C:7]1[CH:12]=[CH:11][N:10]=[C:9]([NH2:13])[N:8]=1)(OC)[CH3:4]>C(O)=O>[NH2:13][C:9]1[N:8]=[C:7]([C:3](=[O:2])[CH3:4])[CH:12]=[CH:11][N:10]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
To 4-(1,1-dimethoxy-ethyl)-pyrimidin-2-ylamine (Step A, 15 g, 81.87 mmol) was added HCOOH (70.0 mL). The resulting mixture was stirred at RT under argon for 3 h. The mixture was evaporated to dryness. The solid was recrystallized from EtOH to give a brown solid. MS m/z:138.2(M+H). Calc'd for C6H8N3O: 138.14.
Workup
- customThe mixture was evaporated to dryness
- customThe solid was recrystallized from EtOH
- customto give a brown solid
Sources & evidence
- ORD record
- ord-50ad7417d71c4cf89b8701774ce486b6
- Source dataset
- uspto-grants-2007_12
- Patent number
- US07307088B2
Reaction notes
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