Ethyl (4-hydroxy-2-methylphenoxy)acetate → Ethyl[4-({5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

HRID 9697

Reaction equation

HRID 9697 reaction equation
C(OC(=O)COC1C=CC(SCC2C=C(C3C=CC(C(F)(F)F)=CC=3)OC=2)=CC=1C)C.[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([OH:44])=[CH:40][C:39]=1[CH3:45])[CH3:33].[F:47][C:48]1[C:53]([F:54])=[C:52]([C:55]([F:58])([F:57])[F:56])[CH:51]=[CH:50][C:49]=1[C:59]1[S:63][C:62]([CH2:64]O)=[C:61]([CH3:66])[CH:60]=1>>[CH2:32]([O:34][C:35](=[O:46])[CH2:36][O:37][C:38]1[CH:43]=[CH:42][C:41]([O:44][CH2:64][C:62]2[S:63][C:59]([C:49]3[CH:50]=[CH:51][C:52]([C:55]([F:56])([F:57])[F:58])=[C:53]([F:54])[C:48]=3[F:47])=[CH:60][C:61]=2[CH3:66])=[CH:40][C:39]=1[CH3:45])[CH3:33]

Participants

4

Reactant 3

HCID 21986458Ethyl (4-hydroxy-2-methylphenoxy)acetate2×HCID 21986476{5-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol2×HCID 21986477Ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate

Product 1

HCID 21986290Ethyl[4-({5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)-2-methylphenoxy]acetate

Procedure

The title compound was prepared by a method analogous to that used for the preparation of ethyl{2-methyl-4-[({5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetate (example 1) using ethyl(4-hydroxy-2-methylphenoxy)acetate (intermediate 7) and {5-[2,3-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methanol (intermediate 122).

Sources & evidence

ORD record
ord-76587a1d5d874959b2ba87d99a8c3da7
Source dataset
uspto-grants-2006_08
Patent number
US07091237B2

Linked notes

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