HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malononitrile → ST050948
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malononitrile | HCID 8010 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Cyclohexanone, 2-hydroxy- | HCID 10785 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | ST050948 | HCID 673083 | 81.9% |
Reaction Steps
2.1 4.8 ml of triethylamine are added dropwise to a solution of 11.0 g of 2-hydroxycyclohexanone and 9.6 g of malononitrile in 25 ml of methanol, and the mixture is stirred at room temperature for a further 4 hours. The crystals which deposit are separated off and washed with methanol, giving 12.8 g of 2-amino-4,5,6,7-tetrahydrobenzofuran-3-carbonitrile (“BA”), m.p. 179°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312224B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-4a7c5bb2c2bb4edc850a4550919d89b8 |
| Source note | uspto-grants-2007_12 |