HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl formate → Diethyl (5-formylfuran-2-yl)phosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl formate | HCID 7865 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Phosphonic acid, 2-furanyl-, diethyl ester | HCID 12485182 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diethyl (5-formylfuran-2-yl)phosphonate | HCID 46784019 | — |
Reaction Steps
solution of diethyl 2-furanphosphonate (1 mmole) in THF was treated with LDA (1.12 mmole, lithium N,N-diisopropylamide) at −78° C. for 20 min. Methyl formate (1.5 mmole) was added and the reaction was stirred for 1 h. Extraction and chromatography gave compound 1 as a clear yellow oil. Preferably this aldehyde can be prepared from 2-furaldehyde as described below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07312219B2 |
| Source dataset | uspto-grants-2007_12 |
| ORD ID | ord-b587e750aa334979877617a0b464899e |
| Source note | uspto-grants-2007_12 |