HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl formate → 2-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl formate | HCID 7865 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Methyltestosterone | HCID 236536 | — |
| Reactant | 4,17alpha-Dimethyl-2-hydroxymethylene Testosterone | HCID 57349609 | — |
| Product | 2-Hydroxymethylene-17beta-hydroxy-4-methylandrost-4-en-3-one | HCID 70603288 | — |
Reaction Steps
2-Hydroxymethylene-17β-hydroxy-4-methylandrost-4-en-3-one was prepared from 32.28 g. of 17β-hydroxy-4-methylandrost-4-en-3-one and 32 ml. of methyl formate by a procedure analogous to that of Example 1, part (c) except that sodium hydride (15 g., 50%) was used in place of sodium methoxide. The 20 g. of product obtained was used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04160027 |
| Source dataset | uspto-grants-1979_07 |
| ORD ID | ord-8c4c7750dc934c27b5fb5795da79a057 |
| Source note | uspto-grants-1979_07 |