Z-Asn-Leu-OMe → H-Asn-Leu-OMe
Reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]>C(O)(C)(C)C.O.[Pd]>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:15]([O:17][CH3:18])=[O:16])[CH2:11][CH:12]([CH3:14])[CH3:13])=[O:8])[CH2:3][C:4](=[O:6])[NH2:5]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
15.0 g of Z-Asn-Leu-OMe are dissolved in 400 ml of t-butanol-water (9:1) and are hydrogenated in the presence of 2 g of palladium on charcoal (10% Pd). After completion of the hydrogenation the catalyst is filtered off and the filtrate evaporated at 40° C. The residue is directly used further.
Workup
- filtrationAfter completion of the hydrogenation the catalyst is filtered off
- customthe filtrate evaporated at 40° C
Sources & evidence
- ORD record
- ord-10fb355f09df4b219259921e9db21399
- Source dataset
- uspto-grants-1979_07
- Patent number
- US04159981
Reaction notes
Loading…