Potassium Hydroxide → 2,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

HRID 972015

Reaction equation

HRID 972015 reaction equation
[CH3:1][C:2]1([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:17]1[CH2:41][CH:18]1[CH2:19][O:20][CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([CH:30]2[CH2:35][CH2:34][CH:33]([O:36][CH2:37][CH:38]3[O:40][CH2:39]3)[CH2:32][CH2:31]2)([CH3:29])[CH3:28])[CH2:23][CH2:22]1.[OH-:42].[K+]>CO>[OH:17][CH:18]([CH2:41][N:6]1[C:5](=[O:42])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:19][O:20][CH:21]1[CH2:22][CH2:23][CH:24]([C:27]([CH:30]2[CH2:31][CH2:32][CH:33]([O:36][CH2:37][CH:38]([OH:40])[CH2:39][N:6]3[C:5](=[O:10])[C:4]4([CH2:3][C:2]([CH3:16])([CH3:1])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]4)[NH:8][C:7]3=[O:9])[CH2:34][CH2:35]2)([CH3:29])[CH3:28])[CH2:25][CH2:26]1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 1145142,2'-((1-Methylethylidene)bis(cyclohexane-4,1-diyloxymethylene))bisoxiraneHCID 12680667,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Product 1

HCID 203967792,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

40.0 g of 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 17.5 g of 2,2-bis[4-(2,3-epoxypropoxy)cyclohexyl]propane and 2.0 g of potassium hydroxide were reacted in 300 ml of methanol, following substantially the same procedure as was described in Example 1. The desired Compound No. 118 was obtained in the form of a white powder, having an Rf value of 0.56 on thin-layer chromatography on silica gel using a 8:1:1:1 by volume mixture of ethyl acetate, benzene, ethanol and triethylamine as developing solvent.

Sources & evidence

ORD record
ord-365dedf39dcc46aca604c0a98528e130
Source dataset
uspto-grants-1979_07
Patent number
US04162246

Linked notes

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