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Potassium Hydroxide → 2,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

HRID 972015
Notes
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Reaction equation

HRID 972015 reaction equation
[CH3:1][C:2]1([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11][C:4]2([NH:8][C:7](=[O:9])[NH:6][C:5]2=[O:10])[CH2:3]1.[O:17]1[CH2:41][CH:18]1[CH2:19][O:20][CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([CH:30]2[CH2:35][CH2:34][CH:33]([O:36][CH2:37][CH:38]3[O:40][CH2:39]3)[CH2:32][CH2:31]2)([CH3:29])[CH3:28])[CH2:23][CH2:22]1.[OH-:42].[K+]>CO>[OH:17][CH:18]([CH2:41][N:6]1[C:5](=[O:42])[C:4]2([CH2:3][C:2]([CH3:1])([CH3:16])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]2)[NH:8][C:7]1=[O:9])[CH2:19][O:20][CH:21]1[CH2:22][CH2:23][CH:24]([C:27]([CH:30]2[CH2:31][CH2:32][CH:33]([O:36][CH2:37][CH:38]([OH:40])[CH2:39][N:6]3[C:5](=[O:10])[C:4]4([CH2:3][C:2]([CH3:16])([CH3:1])[NH:13][C:12]([CH3:15])([CH3:14])[CH2:11]4)[NH:8][C:7]3=[O:9])[CH2:34][CH2:35]2)([CH3:29])[CH3:28])[CH2:25][CH2:26]1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 1145142,2'-((1-Methylethylidene)bis(cyclohexane-4,1-diyloxymethylene))bisoxiraneHCID 12680667,7,9,9-Tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione

Product 1

HCID 203967792,2-Bis{4-[2-hydroxy-3-(7,7,9,9-tetramethyl-2,4-dioxo-1,3,8-triazaspiro[4.5]dec-3-yl)propoxy]cyclohexyl}propane

Reagents, catalysts & solvents 1

HCID 887
Methanol
Solvent

Procedure

40.0 g of 7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione, 17.5 g of 2,2-bis[4-(2,3-epoxypropoxy)cyclohexyl]propane and 2.0 g of potassium hydroxide were reacted in 300 ml of methanol, following substantially the same procedure as was described in Example 1. The desired Compound No. 118 was obtained in the form of a white powder, having an Rf value of 0.56 on thin-layer chromatography on silica gel using a 8:1:1:1 by volume mixture of ethyl acetate, benzene, ethanol and triethylamine as developing solvent.

Sources & evidence

ORD record
ord-365dedf39dcc46aca604c0a98528e130
Source dataset
uspto-grants-1979_07
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04162246

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes