2-Pyridone → N-Phenyl-2-pyridone

Reaction equation

[NH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]1=[O:7].I[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([N:1]2[CH:6]=[CH:5][CH:4]=[CH:3][C:2]2=[O:7])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

Reactant 2

HCID 88712-Pyridone

HCID 11575Iodobenzene

Product 1

HCID 598785N-Phenyl-2-pyridoneYield 82%

Procedure

Following substantially the procedure of Example 1, 2-(1H)-pyridone is condensed with iodobenzene to give the 1-phenyl-2-(1H)-pyridone in 82% yield as a crystalline white product.

Sources & evidence

ORD record: ord-98262728fcc24267bf0148ee4f2d7597
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04052509

Reaction notes

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