Acetic Anhydride → HCID 20263934, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[C:5]([CH2:10][OH:11])=[CH:4][N:3]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>N1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][C:12](=[O:14])[CH3:13])[C:5]([CH2:10][OH:11])=[CH:4][N:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2-Methyl-4,5-di(hydroxymethyl)pyridine (0.1 mole) is stirred in pyridine (50 ml.) with acetic anhydride (0.1 mole) at room temperature overnight. The pyridine is evaporated and the residue is dissolved is 10 ml. water and extracted with 2 × 30 ml. of chloroform. After drying over magnesium sulfate, the chloroform is evaporated and the residue is chromatographed on a silica gel column using benzene-ethanol as eluate. By this procedure is obtained:
Workup
- customThe pyridine is evaporated
- dissolutionthe residue is dissolved
- extractionwater and extracted with 2 × 30 ml
- dry with materialAfter drying over magnesium sulfate
- customthe chloroform is evaporated
- customthe residue is chromatographed on a silica gel column
- customBy this procedure is obtained
Sources & evidence
- ORD record
- ord-34c6489999194555837c8ac770fd53ef
- Source dataset
- uspto-grants-1977_10
- Patent number
- US04053606
Reaction notes
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