L-Alanine → N-(3-Mercaptopropanoyl)-N-methyl-L-leucine

HRID 972898

Reaction equation

CN[C@H](C(O)=O)CC(C)C.N[C@H](C(O)=O)C.C([S:25][CH2:26][CH2:27][C:28]([N:30]([CH3:39])[C@H:31]([C:36]([OH:38])=[O:37])[CH2:32][CH:33]([CH3:35])[CH3:34])=[O:29])(=O)C1C=CC=CC=1.N[C@H](C(O)=O)CC(C)C>>[SH:25][CH2:26][CH2:27][C:28]([N:30]([CH3:39])[C@H:31]([C:36]([OH:38])=[O:37])[CH2:32][CH:33]([CH3:35])[CH3:34])=[O:29]

Participants

Reactant 4

HCID 5950L-Alanine

HCID 6106L-Leucine

HCID 2777993N-Methylleucine

HCID 86735141N-(3-benzoylthiopropanoyl)-N-methyl-L-leucine

Product 1

HCID 53978361N-(3-Mercaptopropanoyl)-N-methyl-L-leucine

Procedure

By substituting N-methyl-L-leucine for the L-alanine in the procedure of Example 1, and then treating the product by the procedure of Example 2, N-(3-benzoylthiopropanoyl)-N-methyl-L-leucine, and N-(3-mercaptopropanoyl)-N-methyl)-L-leucine are obtained.

Workup

customare obtained

Sources & evidence

ORD record: ord-626eb92df9944870b3e7a5b826a896a7
Source dataset: uspto-grants-1977_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04053651

Linked notes

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