Norethisterone Acetate → 3-Oxo-17beta(1oxopropoxy)androst-4en-19-al

https://huagongshe.com/en/reaction/973095

Participants

Role	Name	HCID	Charge
Reactant	Norethisterone Acetate	HCID 5832	—
Reactant	Progesterone	HCID 5994	—
Reactant	Norethindrone	HCID 6230	—
Reactant	Norethynodrel	HCID 6231	—
Reactant	Dydrogesterone	HCID 9051	—
Reactant	Ethynodiol Diacetate	HCID 9270	—
Reactant	Levonorgestrel	HCID 13109	—
Reactant	Dimethisterone Monohydrate	HCID 65320	—
Reactant	acetic acid;(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one	HCID 66742607	—
Reactant	acetic acid;(8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,10,13-trimethyl-2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-3-one	HCID 131710941	—
Product	3-Oxo-17beta(1oxopropoxy)androst-4en-19-al	HCID 86734575	—

Reaction Steps

The composition of claim 25 wherein the progestogen is 17-hydroxy-19-nor-17α-pregn-4-en-20yn-3-one, 17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate, 17-hydroxy-19-nor-17α-pregn-5(10)en-20-yn-3-one, 17-hydroxy-19-nor-17α-pregn-4-en-20-yn, 19-nor-17α-pregn-4-en-20-yne-3β,17-diol diacetate, 3-cyclopentyloxy-19-nor-17α-pregna-3,5-diene-20-yn-17-ol acetate, 16α(R),17-](1phenylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, 17-hydroxy-6α-methylpregn-4-ene-3,20-dione acetate, 17α-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate, 17α-hydroxy-6-methyl-16-methylene-4,6-diene-3,20-dione acetate, 17β-hydroxy-6α-methyl-17-(1-propynyl)androst-4-en-3-one monohydrate, 13-ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one, or 9β,10α-pregna-4,6-diene-3,20-dione.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04054651
Source dataset	uspto-grants-1977_10
ORD ID	ord-b4931d9b65a3428f98c87b516a03f09a
Source note	uspto-grants-1977_10