Acetic Acid → 4-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione

Participants

Reaction Steps

A mixture of 25 g of 1-phenyl-3-anilino-2-pyrazolin-5-one, 18 g of ethyl acetoacetate, and 150 ml of acetic acid was heat-refluxed for 6 hours. The reaction mixture was diluted with water, and the formed solid was crystallized from acetonitrile to obtain 10.9 g of 2,7-diphenyl-4-methylpyrazolo[3,4-b]pyridine-3,6-dione having a melting point of 145° to 147° C.

Provenance & Evidence