3-Aminopropyl(but-3-enyl)phosphinic acid → (3-Aminopropyl)(n-butyl)phosphinic acid
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:8][CH2:9][CH:10]=[CH2:11])(=[O:7])[OH:6].[H][H]>O.[Pd]>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:8][CH2:9][CH2:10][CH3:11])(=[O:6])[OH:7]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 1 g of 3-aminopropyl(but-3-enyl)phosphinic acid in 25 ml of water is treated with 0.1 g of 5% palladium on charcoal and hydrogenated at room temperature until hydrogen uptake ceases. The catalyst is removed by filtration of the reaction mixture through celite and the filtrate evaporated to dryness, to afford 3-aminopropyl(butyl)-phosphinic acid, m.p. 231°-234° (dec.) 31 -NMR (D2O): δ±44.6 ppm.
Workup
- customThe catalyst is removed by filtration of the reaction mixture through celite
- customthe filtrate evaporated to dryness
Sources & evidence
- ORD record
- ord-1e2c3f361ed840cc92bd575aec65e39c
- Source dataset
- uspto-grants-1991_11
- Patent number
- US05064819
Reaction notes
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