Ammonia → 6-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-3(2H)-pyridazinone

Participants

Reaction Steps

A stirred mixture of 6-(4-aminophenyl)-3(2H) -pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.71 g), and water (20 ml), was heated under reflux for 2 hours. The pH of the hot solution was adjusted to 8 with aqueous ammonia and the mixture was cooled to give the crude product, 1.84 g, m.p. 338-340° C. Recrystallisation from aqueous ethanol gave the title compound, 1,4 g, m.p. 339-341° C.

Provenance & Evidence