1-Methoxycarbonylmethyl-7,8-dihydro-2,5(1H,6H)-quinolinedione → 1-Carboxymethyl-7,8-dihydro-2,5(1H,6H)-quinolinedione
Reaction equation
C[O:2][C:3]([CH2:5][N:6]1[C:15]2[CH2:14][CH2:13][CH2:12][C:11](=[O:16])[C:10]=2[CH:9]=[CH:8][C:7]1=[O:17])=[O:4]>[OH-].[Na+]>[C:3]([CH2:5][N:6]1[C:15]2[CH2:14][CH2:13][CH2:12][C:11](=[O:16])[C:10]=2[CH:9]=[CH:8][C:7]1=[O:17])([OH:4])=[O:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared by saponification from 1-methoxycarbonylmethyl-7,8-dihydro-2,5(1H,6H)-quinolinedione in 1 N sodium hydroxide solution at room temperature. The reaction mixture was adjusted to pH 2 after two hours and extracted with ethyl acetate.
Workup
- extractionextracted with ethyl acetate
Sources & evidence
- ORD record
- ord-9e78e31439ec4c3194d8dd34d7971655
- Source dataset
- uspto-grants-1991_11
- Patent number
- US05068334
Reaction notes
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