2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → 2-Amino-6-(3-(3-furyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974291

Reaction equation

HRID 974291 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH:6]=[CH:7][CH2:8]Cl)=[CH:2]1.[NH2:10][C:11]1[S:12][C:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18][C:19]=2[N:20]=1>C(Cl)(Cl)Cl>[NH2:10][C:11]1[S:12][C:13]2[CH2:14][CH2:15][N:16]([CH2:8][CH:7]=[CH:6][C:3]3[CH:4]=[CH:5][O:1][CH:2]=3)[CH2:17][CH2:18][C:19]=2[N:20]=1

Participants

4

Reactant 2

HCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 542309893-(3-Furyl)allyl chloride

Product 1

HCID 540180432-Amino-6-(3-(3-furyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepineYield 30%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 3-(3-furyl)allyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in chloroform. Yield: 30% of theory, Melting point: 130°-136° C.

Sources & evidence

ORD record
ord-ed227eabd81d438d9c4eb178c74fdd99
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Linked notes

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