Diethyl Ether → 2-Amino-6-(3-(2-nitro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

HRID 974293

Reaction equation

HRID 974293 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[CH:6]=[CH:7][CH2:8]Cl)([O-:3])=[O:2].[NH2:14][C:15]1[S:16][C:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22][C:23]=2[N:24]=1.CCOCC>C(Cl)(Cl)Cl>[NH2:14][C:15]1[S:16][C:17]2[CH2:18][CH2:19][N:20]([CH2:8][CH:7]=[CH:6][C:5]3[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=3[N+:1]([O-:3])=[O:2])[CH2:21][CH2:22][C:23]=2[N:24]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 544529242-Nitro-cinnamyl chloride

Product 1

HCID 539132892-Amino-6-(3-(2-nitro-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepineYield 57%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 2-nitro-cinnamyl chloride and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine in chloroform. Yield: 57% of theory, Melting point: 125°-128° C. (ether).

Sources & evidence

ORD record
ord-1cb288f16886405c8746264aefe43dd6
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Linked notes

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