2,4-Dimethoxytetrahydrofuran → 1H-Pyrrole, 1-[3-(2,4-difluorophenyl)propyl]-

HRID 974397

Reaction equation

HRID 974397 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][NH2:12].CO[CH:15]1[CH2:19][CH:18](OC)[CH2:17]O1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][N:12]1[CH:15]=[CH:19][CH:18]=[CH:17]1

Participants

3

Reactant 2

HCID 199863682,4-DimethoxytetrahydrofuranHCID 22669139HCID 22669139, compound

Product 1

HCID 199863711H-Pyrrole, 1-[3-(2,4-difluorophenyl)propyl]-

Procedure

17.1 g (0.10 mol) of 3-(2,4-difluorophenyl)propylamine are heated at 260° C. for 2 hours in an autoclave with 13.2 g (0.10 mol) of 2,4-dimethoxytetrahydrofuran. The reaction mixture is cooled and then purified by vacuum distillation. 10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained.

Workup

  1. temperatureThe reaction mixture is cooled
  2. distillationpurified by vacuum distillation
  3. custom10.6 g (48% of theory) of a colourless oil which boils at 80° C. and 0.2 mbar or 146°-147° C. and 15 mbar are obtained

Sources & evidence

ORD record
ord-54f1e1a3b3494f0d8649e77445d4fe39
Source dataset
uspto-grants-1991_11
Patent number
US05068371

Linked notes

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