Formaldehyde → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane
Reaction equation
[CH2:1]=O.[OH:3][CH2:4][CH:5]1[CH2:9][NH:8][CH2:7][CH:6]1[NH:10][CH3:11]>C(O)CCC>[CH3:11][N:10]1[CH2:1][O:3][CH2:4][CH:5]2[CH:6]1[CH2:7][NH:8][CH2:9]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
8.1.g (0.1 mol) of 37% strength formaldehyde solution in 20 ml of n-butanol are added dropwise to 13 g (0.101 mol) of 4-hydroxymethyl-3-methylaminopyrrolidine in 100 ml of n-butanol at room temperature. The mixture is stirred at room temperature overnight and concentrated and the residue is distilled.
Workup
- concentrationconcentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-2e5892f5ccbd453690f30fd4ea281b2f
- Source dataset
- uspto-grants-1997_03
- Patent number
- US05607942
Reaction notes
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