Diethyl Ether → HCID 19970292, compound
Reaction equation
[C:1]([C:3]1[CH:12]=[CH:11][C:6]([C:7](=O)[CH2:8][Br:9])=[CH:5][CH:4]=1)#[N:2].[BrH:13].[CH2:14]([N:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:28]([NH2:30])=[S:29])[CH2:23][CH2:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(OCC)C>CO>[BrH:9].[BrH:13].[CH2:14]([N:21]1[CH2:22][CH2:23][CH:24]([NH:27][C:28]2[S:29][CH:8]=[C:7]([C:6]3[CH:11]=[CH:12][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[N:30]=2)[CH2:25][CH2:26]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
12.46 g of 4-cyanophenacyl bromide are added to 18.38 g of N-(1-benzylpiperid-4-yl)thiourea hydrobromide in 200 ml of methanol, and then the reaction mixture is heated under reflux for 4 hours. The mixture is cooled to room temperature and then, successively, 200 ml of diethyl ether are added and the precipitate is filtered and washed with diethyl ether in order to obtain white crystals which melt at 280° C.; yield: 86%.