3-Buten-2-ol → 5-(3-Hydroxy-1-but-1-enyl)-3-(N-methyl-4-piperidyl)-1H-indole

HRID 975144

Reaction equation

HRID 975144 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][CH:19]([OH:22])[CH:20]=[CH2:21]>C(Cl)Cl>[OH:22][CH:19]([CH3:18])[CH:20]=[CH:21][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 117163-Buten-2-olHCID 157453445-bromo-3-(1-methylpiperidin-4-yl)-1H-indole

Product 1

HCID 540865635-(3-Hydroxy-1-but-1-enyl)-3-(N-methyl-4-piperidyl)-1H-indole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Obtained by a procedure similar to that described in Example 1, using 5-bromo-3-(N-methyl-4-piperidyl)-1H-indole (EP-A-0303507) and but-3-en-2-ol, as a foam. Rf 0.50 (SS 4). Found: C,72.85; H,8.22; N,9.17. C18H24N2O; 0.17 CH2Cl2 requires C,73.08; H,8.22; N,9.38%.

Workup

  1. customObtained by a procedure similar to

Sources & evidence

ORD record
ord-4a1b766f7e0f4601935c4348928aa0dd
Source dataset
uspto-grants-1997_03
Patent number
US05607960

Linked notes

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