HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 975320Generated: October 26, 2026
Dimethylformamide → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester
https://huagongshe.com/reaction/975320
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester | HCID 15121177 | — |
Reaction Steps
14.5 g (80 mmol) of 2-methoxycarbonylpyridine-5-carboxylic acid are treated with 6.48 ml of thionyl chloride and 2 ml of anhydrous N,N-dimethylformamide in 200 ml of anhydrous toluene. The mixture is heated at 70° C. for 3 h with stirring. It is then concentrated in vacuo and the residue is dissolved in 150 ml of tetrahydrofuran.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05607954 |
|---|
| Source dataset | uspto-grants-1997_03 |
|---|
| ORD ID | ord-b7ff8f5cd07e44dab300a97985b59738 |
|---|
| Source note | uspto-grants-1997_03 |
|---|
